General
Preferred name
ABAMETAPIR
Synonyms
HA-44 ()
BRN 0123183 ()
HA-44, BRN 0123183 ()
Xeglyze ()
HA44 ()
5,5'-dimethyl-2,2'-dipyridyl ()
6,6'-bi-3-picoline ()
P&D ID
PD058861
CAS
1762-34-1
Tags
available
drug
Approved by
FDA
First approval
2020
Drug indication
lice infestation
Head and body lice
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Abametapir is a metalloproteinase (MMP) inhibitor which is able to target metalloproteinases critical to egg hatching and louse development. Abametapir can inhibit hatching of both head and body louse[1][2].
PRICE 29
DESCRIPTION Abametapir is a novel pediculicidal metalloproteinase inhibitor. Abametapir is indicated, in the context of an overall lice management program, for the topical treatment of head lice infestation in patients 6 months of age and older. (Enamine Bioactive Compounds)
DESCRIPTION Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development. (TargetMol Bioactive Compound Library)
Compound Sets
19
AdooQ Bioactive Compound Library
A15945
Cayman Chemical Bioactives
30684
ChEMBL Approved Drugs
CHEMBL2205807
ChEMBL Drugs
CHEMBL2205807
Drug Repurposing Hub
DrugBank
DB11932
DrugBank Approved Drugs
DB11932
DrugCentral
5403
DrugCentral Approved Drugs
5403
DrugMAP
DM2RX0I
DrugMAP Approved Drugs
DM2RX0I
Enamine Bioactive Compounds
EBC-03993
Enamine BioReference Compounds
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL2205807
MedChem Express Bioactive Compound Library
HY-W004546
ReFrame library
Selleckchem Bioactive Compound Library
abametapir
TargetMol Bioactive Compound Library
T7459
ZINC Tool Compounds
ZINC000000403335
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
184.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
2.76
TPSA
25.78
Fraction CSP3
0.17
Chiral centers
0.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
metalloproteinase
MMP
Parasite
MMP9
MOA
metalloproteinase inhibitor
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Source data