General
Preferred name
Lurbinectedin
Synonyms
PM01183 ()
LY-01017 ()
Zepsyre ()
Pm01183 ()
Zepzelca ()
PM1183 ()
PM-1183 ()
PM-01183 ()
Lurbinectedina ()
Lurbinectedine ()
Tryptamicidin ()
P&D ID
PD058822
CAS
497871-47-3
Tags
available
drug
Approved by
FDA
First approval
2020
Drug indication
Endometrial cancer
Small-cell lung cancer
Ovarian cancer
Neoplasm
Solid tumour/cancer
leukaemia
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 4117
DESCRIPTION Lurbinectedin (PM01183) is a DNA minor groove covalent binder that demonstrates effective anti-tumor activity.
DESCRIPTION Lurbinectedin (PM01183) is an investigational anti-tumour agent with potential activity against a wide range of tumours. Structurally it is a synthetic tetrahydroisoquinoline that is related to the marine ecteinascidins (e.g. ). Like trabectedin, lurbinectedin binds to the minor groove of DNA. Stable lurbinectedin-DNA adducts induce DNA double- and single-strand breaks which cause cell cycle arrest and ultimately, apoptotic cell death. (GtoPdb)
Compound Sets
13
ChEMBL Approved Drugs
CHEMBL4297516
ChEMBL Drugs
CHEMBL4297516
Drug Repurposing Hub
DrugBank
DB12674
DrugBank Approved Drugs
DB12674
DrugCentral
5398
DrugCentral Approved Drugs
5398
DrugMAP
DMEFRTZ
DrugMAP Approved Drugs
DMEFRTZ
Guide to Pharmacology
10681
MedChem Express Bioactive Compound Library
HY-16293
NCATS Inxight Approved Drugs
2CN60TN6ZS
ReFrame library
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
784.28
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
3
Ring Count
11
Aromatic Ring Count
4
cLogP
4.19
TPSA
164.28
Fraction CSP3
0.46
Chiral centers
7.0
Largest ring
10.0
QED
0.17
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
MOA
DNA binding agent
Target
DNA alkylator/crosslinker
DNA/RNA Synthesis
Pathway
Cell Cycle/DNA Damage
Source data