General
Preferred name
Relamorelin
Synonyms
BIM28131 ()
RM 131 ()
BIM-28131 ()
BIM-28163 ()
BIM 28163 ()
BIM28163 ()
BIM 28131 ()
Relamorelin (TFA) ()
RM-131 (TFA) ()
BIM-28131 (TFA) ()
Relamorelina ()
Relamoreline ()
P&D ID
PD058816
CAS
2863659-22-5
661472-41-9
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Relamorelin(BIM28131, RM131) is a selective and potent ghrelin/growth hormone secretagogue receptor (GHSR) agonist with high affinity for GHS-1a receptor (Ki value is 0.42 ± 0.063 nM). Relamorelin(BIM28131, RM131) is also a centrally permeable pentapeptide analog that can increase growth hormone levels and accelerate gastric emptying, and has the potential to study cachexia.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
ChEMBL Drugs
DrugBank
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
790.36
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
8
Rotatable Bonds
15
Ring Count
7
Aromatic Ring Count
5
cLogP
2.59
TPSA
199.34
Fraction CSP3
0.37
Chiral centers
3.0
Largest ring
6.0
QED
0.08
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
hormone-releasing factor (GHRF)
GHSR
Pathway
GPCR/G protein
Source data
