General
Preferred name
TRIBUTYRIN
Synonyms
Glyceryl tributyrate ()
Glycerol Tributyrate ()
NSC-661583 ()
Butyrin ()
FEMA NO. 2223 ()
P&D ID
PD058804
CAS
60-01-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Prostate cancer
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed proagent of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1].
DESCRIPTION Tributyrin is a triglyceride metabolite that has been isolated from the single-celled alga Euglena gracilis and the nematode Caenorhabditis elegans. It has a bitter or acrid taste. (GtoPdb)
Compound Sets
8
ChEMBL Drugs
CHEMBL118722
Concise Guide to Pharmacology 2023/24
12450
Drug Repurposing Hub
DrugBank
DB12709
Guide to Pharmacology
12450
MedChem Express Bioactive Compound Library
HY-W011404
ReFrame library
Selleckchem Bioactive Compound Library
glycerol-tributyrate
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
302.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
11
Ring Count
0
Aromatic Ring Count
0
cLogP
2.38
TPSA
78.9
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.43
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
MOA
HDAC inhibitor
Target
Apoptosis
Interleukin Related
TNF Receptor
Pathway
Immunology/Inflammation
Source data