General
Preferred name
MIBAMPATOR
Synonyms
LY451395 ()
LY 451395 ()
LY-451395 ()
P&D ID
PD058798
CAS
375345-95-2
Tags
available
drug candidate
Drug indication
Alzheimer disease
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
PRICE 80
DESCRIPTION Incubation of LY451395 with Actinoplanes missouriensis NRRL B3342 generated several metabolites that were previously detected in the in vivo metabolism studies of the preclinical species. LY404187 and LY451395 reverses the central effects of an acutely intoxicating dose of ethanol in the rat. LY451395 significantly and dose-dependently reversed ethanol-induced deficits in both motor coordination and disruptions in an operant task where animals were trained to press a lever for food reward. (BOC Sciences Bioactive Compounds)
DESCRIPTION Mibampator (LY451395) is an effective and selective AMPA receptor potentiator. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
BOC Sciences Bioactive Compounds
ly451395-cas-375345-95-2-item-84-459100
ChEMBL Drugs
CHEMBL1277001
Drug Repurposing Hub
DrugBank
DB12717
DrugMAP
DME5CSV
MedChem Express Bioactive Compound Library
HY-10934
ReFrame library
TargetMol Bioactive Compound Library
T15820
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
438.16
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
2
cLogP
2.88
TPSA
92.34
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Target
GRIA1
iGluR
AMPAR
MOA
glutamate receptor modulator
Source data