General
Preferred name
ELAMIPRETIDE
Synonyms
Elamipretide (TFA) ()
MTP-131 (TFA) ()
RX-31 (TFA) ()
SS-31 (TFA) ()
Elamipretide TriTFA ()
MTP-131 ()
RX-31 ()
SS-31 ()
SS-31, D-Arg-Dmt-Lys-Phe-NH2 ()
Elamipretide (MTP-131) ()
Elamipretide Triacetate ()
ELAMIPRETIDE HYDROCHLORIDE ()
Ocuvia ()
RX 31 ()
RX31 ()
SS31 ()
MTP131 ()
SS 31 ()
Szeto-schiller peptide ()
MTP 131 ()
Elamipretida ()
Nh2-d-arg-dmt-lys-phe-nh2 ()
Elamipretide trihydrochloride ()
Bendavia ()
MTP 131 (acetate) ()
P&D ID
PD058756
CAS
736992-21-5
1849610-71-4
1334953-95-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
3.0
Drug indication
Age-related macular degeneration
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Elamipretide (MTP-131) is a mitochondria-targeting peptide, which ameliorates myocardial infarction, improves the renal function and protects neurons form inflammatory and oxidative stress injury[1][2].
DESCRIPTION Elamipretide (MTP-131) is a mitochondria-targeted antioxidant tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that reduces toxic reactive oxygen species (ROS) production and stabilizes cardiolipin, with blood-brain-barrier permeability. It is a potential therapeutic agent in the rare disease of Barnes syndrome. (TargetMol Bioactive Compound Library)
DESCRIPTION Elamipretide Triacetate (Elamipretide TriTFA) is an aromatic-cationic tetrapeptide that readily penetrates cell membranes and transiently localizes to the inner mitochondrial membrane where it associates with cardiolipin.It has been used in trials studying the treatment of Leber's Hereditary Optic Neuropathy. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
33302
ChEMBL Drugs
CHEMBL3833370
CHEMBL4298161
DrugBank
DB11981
MedChem Express Bioactive Compound Library
HY-P0125
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
elamipretide-mtp-131
TargetMol Bioactive Compound Library
TP1095
T8644
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
639.39
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
10
Rotatable Bonds
19
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.55
TPSA
264.56
Fraction CSP3
0.47
Chiral centers
4.0
Largest ring
6.0
QED
0.05
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolic Enzyme/Protease
Target
Mitochondrial Metabolism
Cardiolipin peroxidase
Mitochondrial Metabolism,Peroxidases
Source data