General
Preferred name
MAPRACORAT
Synonyms
ZK-245186 ()
BOL-303242X ()
BOL-303242-X ()
ZK 245186 ()
P&D ID
PD058726
CAS
887375-26-0
Tags
available
drug candidate
Drug indication
Ocular disease
Drug Status
investigational
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Mapracorat is a novel non-steroidal selective glucocorticoid receptor agonist (SEGRA) . SEGRAs exert their pharmacological effect by activating only the transrepression pathway, which is in contrast to traditional glucocorticosteroids (GCs) which activate both the transactivation and transrepression pathways.The pharmaceutical industry is trying to develop new GCs that are as effective as traditional GCs, but with fewer limiting adverse effects. Mapracorat and are prototype compounds that were designed to address this clinical need. (GtoPdb)
Compound Sets
6
ChEMBL Drugs
CHEMBL2103876
DrugBank
DB12041
DrugMAP
DMR23M1
Guide to Pharmacology
9654
MedChem Express Bioactive Compound Library
HY-14864
ReFrame library
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
462.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
5.69
TPSA
54.38
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Target
Glucocorticoid Receptor
Source data