General
Preferred name
Savolitinib
Synonyms
AZD-6094, Savolitinib ()
Volitinib ()
HMPL-504 ()
AZD-6094 ()
AZD6094 ()
Savolitinib (AZD6094) ()
HMPL-504, Volitinib ()
P&D ID
PD058722
CAS
1313725-88-0
Tags
available
drug
probe
Drug indication
Renal cell carcinoma
Solid tumour/cancer
Drug Status
investigational
approved
Max Phase
3.0
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Savolitinib is a potent and selective, ATP-competitive mesenchymal-epithelial transition factor (c-Met) inhibitor that was designed for anti-cancer potential . In this discovery report it was called volitinib, but the designated INN is savolitinib. Research codes are HMPL-504 and AZD6094. (GtoPdb)
Cell lines
2
Organisms
0
Compound Sets
15
AdooQ Bioactive Compound Library
A14419
Cayman Chemical Bioactives
33332
ChEMBL Drugs
CHEMBL3334567
Clinical kinase drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12048
DrugMAP
DMALFKX
Guide to Pharmacology
9918
MedChem Express Bioactive Compound Library
HY-15959
PKIDB
Probe Miner (suitable probes)
P08581/1700223
ReFrame library
Selleckchem Bioactive Compound Library
hmpl-504-azd6094-volitinib
TargetMol Bioactive Compound Library
TQ0210
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
345.15
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
5
cLogP
1.88
TPSA
91.61
Fraction CSP3
0.18
Chiral centers
1.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Targets
MET
Pathway
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
c-Met
c-Met/HGFR
MOA
c-Met inhibitor
Source data