General
Preferred name
CENSAVUDINE
Synonyms
OBP-601 ()
Festinavir ()
BMS-986001 ()
4'-Ethynyl Stavudine ()
4'-Ethynylstavudine ()
4'-ed4t ()
Censavudine, 4'-ethynyl-d4t ()
P&D ID
PD058693
CAS
634907-30-5
Tags
available
drug candidate
prodrug
Drug indication
Human immunodeficiency virus-1 infection
Drug Status
investigational
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Censavudine is a nucleoside reverse transcriptase inhibitor. It is active against HIV resistant to both abacavir and tenofovir. It is a candidate for people with multi-drug resistant (MDR) strains of the virus. It is a derivative of stavudine (d4T), but is less toxic. It has demonstrated potent in vitro activity against HIV-2. It was developed by Bristol Myers-Squibb and in clinic phase 2 trials. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
7
BOC Sciences Bioactive Compounds
censavudine-cas-634907-30-5-item-476063
Cayman Chemical Bioactives
37668
ChEMBL Drugs
CHEMBL124363
DrugBank
DB12074
DrugMAP
DMVXZC4
MedChem Express Bioactive Compound Library
HY-16776
ReFrame library
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
248.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.71
TPSA
84.32
Fraction CSP3
0.33
Chiral centers
2.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Anti-infection
Cell Cycle/DNA Damage
Target
HIV
Nucleoside antimetabolite/analog
Reverse Transcriptase
Solubility
Soluble in DMSO, not in water
Source data