General
Preferred name
Vaborbactam
Synonyms
Vabomere-vaborbactam ()
PH-CBR-2016-001-HVAC-07200-0 ()
RPX7009 ()
RPX-7009 ()
1448232-80-1 ()
P&D ID
PD058676
CAS
1360457-46-0
1360457-46-01
Tags
covalent binder
drug
available
Approved by
FDA
First approval
2017
Drug Status
investigational
approved
Drug indication
Urinary tract infection
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Vaborbactam is a β-lactamase inhibitor . Structurally it is based on a cyclic boronic acid pharmacophore.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
297.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
0.45
TPSA
95.86
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
beta lactamase inhibitor
Biosynthetic Origin
Peptide (beta-Lactam)
Therapeutic Indication
Antibacterial
Therapeutic Class
Antimicrobial
Pathway
Anti-infection
Target
Bacterial
Beta-lactamase
Source data
