General
Preferred name
Brincidofovir
Synonyms
HEXADECYLOXYPROPYL CIDOFOVIR ()
CMX001 ()
HDP-CDV ()
Brincidofovir (CMX001) ()
CMX-001 ()
Hdp-cidofovir ()
Hexadecyloxypropyl-cidofovir ()
CMX 001 ()
Tembexa ()
Hexadecyloxypropyl Cidofovir ()
P&D ID
PD058648
CAS
444805-28-1
Tags
available
prodrug
drug
Drug indication
Cytomegalovirus infection
Solid tumour/cancer
Drug Status
approved
investigational
Max Phase
4.0
First approval
2021
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 187
DESCRIPTION Brincidofovir is an orally bioavailable, lipid-conjugated (to enhance cellular penetration) ester prodrug of the acyclic nucleoside monophosphate antiviral cidofovir. The active metabolite is cidofovir diphosphate, which disrupts viral DNA polymerase activity and viral DNA replication. Brincidofovir has been investigated for infections caused by several virus families, including cytomegalovirus (CMV), BK virus (BKV), adenoviruses (AdV) , HPV , and Epstein-Barr virus (EBV), as well as for smallpox (Variola) infections.
A molecular docking study has indicated that brincidofovir interacts with both host ACE2 and SARS-CoV-2 3C-like (main) protease . Further studies would be required to validate brincidofovir as a potential therapy for SARS-CoV-2 infection. (GtoPdb)
DESCRIPTION Brincidofovir (HDP-CDV) is an orally active, lipophilic form of cidofovir. It has enhanced activity compared to CDV against certain adenoviruses, herpesviruses, and orthopoxviruses. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
7
Compound Sets
13
AdooQ Bioactive Compound Library
A13326
Cayman Chemical Bioactives
35062
ChEMBL Approved Drugs
CHEMBL203321
ChEMBL Drugs
CHEMBL203321
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB12151
DrugBank Approved Drugs
DB12151
DrugMAP
DM9Y3B5
Guide to Pharmacology
11556
MedChem Express Bioactive Compound Library
HY-14532
ReFrame library
TargetMol Bioactive Compound Library
TQ0095
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
561.35
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
26
Ring Count
1
Aromatic Ring Count
1
cLogP
5.25
TPSA
146.13
Fraction CSP3
0.85
Chiral centers
2.0
Largest ring
6.0
QED
0.1
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Immunology/Inflammation
Microbiology/virology
Anti-infection
MOA
Antiviral
Target
CMV
HSV
Orthopoxvirus
Source data