General
Preferred name
CARBENDAZIM
Synonyms
Mercarzole, Carbendazole ()
methyl N-(1H-1,3-benzodiazol-2-yl)carbamate ()
FB-642 ()
EK-578 ()
Bavistin ()
NSC-109874 ()
Derroprene ()
Lignasan ()
BAS-67054F ()
A118 ()
A 118 ()
Thicoper ()
Fenbendazole related compound a ()
P&D ID
PD058629
CAS
37953-07-4
102040-01-7
10605-21-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
1.0
Drug indication
Neoplasm
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Carbendazim is a potent and orally active broad-spectrum?benzimidazole fungicide and can be acts as a pesticide for fungal diseases research, such as Seproria,?Fusarium?and?Sclerotina[1][3]. Carbendazim is a benzimidazole (HY-Y1825) derivative with antitumor activity and used for cancer research, especially advanced solid tumors and lymphoma[3].
PRICE 29
DESCRIPTION Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspecified site on tubulin and suppresses microtubule assembly dynamic. This results in cell cycle arrest at the G2/M phase and an induction of apoptosis.
DESCRIPTION Fungicide. Carbendazim is the degradation product and active ingredient of the carbamate fungicide benomyl. (Enamine Bioactive Compounds)
DESCRIPTION PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
5
Compound Sets
11
Cayman Chemical Bioactives
23852
ChEMBL Drugs
CHEMBL70971
Drug Repurposing Hub
DrugBank
DB13009
Enamine Bioactive Compounds
EBC-04390
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-13582
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
carbendazim
TargetMol Bioactive Compound Library
0342-0097
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
191.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.74
TPSA
67.01
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Indication
fungicide
Target
TP53, TUBB
Fungal
Parasite
MOA
microtubule inhibitor, tubulin polymerization inhibitor
Pathway
Anti-infection
Source data