General
Preferred name
Clascoterone
Synonyms
Cortexolone 17¦Á-propionate ()
Cortexolone 17 alpha-propionate ()
17 alpha-propionate ()
CB-03-01 ()
Cortexolone 17α-propionate ()
Cortexolone 17alpha-propionate ()
Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17¦Á-propionate, CB-03-01 ()
Clascoterona ()
Breezula ()
Winlevi ()
Cortexolone 17.alpha.-propionate ()
Cortodoxone 17.alpha.-propionate ()
Cortexolone 17?-propionate ()
P&D ID
PD058609
CAS
19608-29-8
Tags
available
drug
Approved by
FDA
First approval
2020
Drug indication
acne
Acne vulgaris
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17¦Á-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.
DESCRIPTION
Clascoterone is a steroidal androgen receptor antagonist (antiandrogen) . It was developed to address the hormonal pathogenesis of acne . It has been shown to inhibit production of lipids and inflammatory cytokines from sebocytes .
(GtoPdb)
DESCRIPTION
Clascoterone (CB-03-01) is a new topical and peripherally selective androgen antagonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
402.24
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
0
cLogP
3.77
TPSA
80.67
Fraction CSP3
0.79
Chiral centers
6.0
Largest ring
6.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Androgen Receptor
AR
MOA
Androgen Receptor antagonist
Pathway
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Source data
