General
Preferred name
BI-671800
Synonyms
AP-761 ()
Cmpd A ()
AP-761, Cmpd A ()
BI671800 ()
BI 671800 ()
Actimis ()
P&D ID
PD058593
CAS
1093108-50-9
Tags
available
drug candidate
Drug indication
Asthma
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively[1]. BI-671800 has potential for the treatment of poorly controlled asthma[2].
PRICE 218
DESCRIPTION BI671800 is a CRTH2 antagonist. It is used to treat patients with asthma. It is associated with a small improvement in FEV1 in symptomatic controller-naïve asthma patients, and in patients on inhaled corticosteroid (ICS) therapy. (BOC Sciences Bioactive Compounds)
DESCRIPTION BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has the potential to treat poorly controlled asthma[2]. (TargetMol Bioactive Compound Library)
Compound Sets
9
BOC Sciences Bioactive Compounds
bi671800-cas-1093108-50-9-item-475050
Cayman Chemical Bioactives
27638
ChEMBL Drugs
CHEMBL551813
DrugBank
DB12524
DrugMAP
DMISQOZ
MedChem Express Bioactive Compound Library
HY-114141
ReFrame library
Selleckchem Bioactive Compound Library
ap-761-bi671800
TargetMol Bioactive Compound Library
T14565
External IDs
17
Properties
(calculated by RDKit )
Molecular Weight
501.2
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
4.1
TPSA
98.66
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Prostaglandin Receptor
CRTh2 (DP2) receptor
hCRTH2
mCRTH2
CRTH2 (GPR44)
Pathway
Endocrinology/Hormones
GPCR/G protein
Immunology/Inflammation
Solubility
10 mM in DMSO
Source data