General
Preferred name
PYRAZOLOACRIDINE
Synonyms
PD-115934 ()
NSC 366140 ()
NSC-366140 ()
PD 115,934 ()
PD 115934 ()
NSC-627168 ()
P&D ID
PD058567
CAS
99009-20-8
Tags
available
drug candidate
nuisance
Drug indication
Cutaneous melanoma
Colorectal cancer
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pyrazoloacridine (NSC 366140), an intercalating agent with anti-cancer activity, inhibits the activity of topoisomerases 1 and 2. Pyrazoloacridine (NSC 366140) exhibits an IC50 of 1.25 ¦ÌM in K562 myeloid leukemia cells for 24 h treatment[1][2].
PRICE 98
DESCRIPTION Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 ??M in K562 cells. Pyrazoloacridine shows anti-cancer activity.
DESCRIPTION Pyrazoloacridine (PD 115934) is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
8
ChEMBL Drugs
CHEMBL118841
DrugBank
DB12549
DrugMAP
DMSOPAU
DrugMatrix
MedChem Express Bioactive Compound Library
HY-108969
Nuisance compounds in cellular assays
ReFrame library
TargetMol Bioactive Compound Library
T28475
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
367.16
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
3.63
TPSA
85.46
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
1
Intercalation
Nuisance compounds
Custom attributes
(extracted from source data)
Target
Topo I
Topo II
Apoptosis
Topoisomerase
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Source data