General
Preferred name
EMIXUSTAT
Synonyms
ACU-4429 hydrochloride ()
Emixustat (hydrochloride) ()
ACU-4429 ()
EMIXUSTAT HYDROCHLORIDE ()
ACU-4429 HCL ()
ACU-4429 HYDROCHLORIDE ()
ACU 4429 (hydrochloride) ()
P&D ID
PD058523
CAS
1141777-14-1
1141934-97-5
Tags
available
drug candidate
Drug indication
atrophic macular degeneration
Proliferative diabetic retinopathy
Age-related macular degeneration
Drug Status
investigational
Max Phase
3.0
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Emixustat is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD)[1][2][3][4].
DESCRIPTION
Emixustat (ACU-4429) hydrochloride is an orally active RPE65 inhibitor with an IC50 value of 4.4 nM. Emixustat hydrochloride is also a visual cycle modulator, capable of regulating visual cycle activity by inhibiting retinol isomerization, and holds potential for studying vision disorders such as age-related macular degeneration (AMD)[1][2][3][4].
PRICE
137
DESCRIPTION
Emixustat hydrochloride (ACU-4429 hydrochloride) strongly inhibits 11-cis-retinol production with IC50 values of 232 ?? 3 nM. 11-cis-retinol Emixustat hydrochloride is a novel visual cycle modulator.
DESCRIPTION
The hydrochloride salt form of Emixustat which could effectively inhibit the production of 11-cis-retinol which is related to age-related macular degeneration.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Emixustat hydrochloride (ACU-4429 hydrochloride) strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. 11-cis-retinol Emixustat hydrochloride is a novel visual cycle modulator.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugMAP
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
263.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
3.03
TPSA
55.48
Fraction CSP3
0.62
Chiral centers
1.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Retinoid Isomerohydrolase (RPE65) Inhibitors
retinoid isomerohydrolase inhibitor
Target
RPE65
Pathway
Metabolic Enzyme/Protease
Solubility
DMSO: > 44 mg/mL
Source data
