General
Preferred name
MRX-I
Synonyms
MRXI ()
MRX I ()
CONTEZOLID ()
MRX-1 ()
P&D ID
PD058458
CAS
1112968-42-9
Tags
available
drug
Drug indication
MRSA infection
bacterial disease
Skin infection
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid (MRX-I) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI)[1][2].
PRICE 871
DESCRIPTION Contezolid is an oxazolidinone antibacterial against Gram-positive pathogens , including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae, penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). Its orally delivered prodrug is (MRX-4). Contezolid targets protein synthesis by binding to the V region of the bacterial 23S rRNA. (GtoPdb)
DESCRIPTION Contezolid (MRX-I) is an orally available oxazolidinone antibiotic with bactericidal activity that can be used to study complications of skin tissue infections and tuberculosis caused by drug-resistant Gram-positive bacteria. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Drugs
CHEMBL3287379
DrugBank
DB12796
DrugMAP
DMZ0F65
Guide to Pharmacology
10795
MedChem Express Bioactive Compound Library
HY-19915
ReFrame library
TargetMol Bioactive Compound Library
T28109
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
408.1
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
2
cLogP
2.82
TPSA
87.91
Fraction CSP3
0.28
Chiral centers
1.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
antibiotic
Antibacterial
Bacterial
Monoamine Oxidase
Pathway
Microbiology/virology
Anti-infection
Neuronal Signaling
Source data