General
Preferred name
ZOLIFLODACIN
Synonyms
ETX0914 ()
AZD0914 ()
Zoliflodacina ()
Zoliflodacine ()
ETX-0914 ()
AZD-0914 ()
P&D ID
PD058438
CAS
1620458-09-4
Tags
drug candidate
available
Drug indication
gonorrhea
Neisseria gonorrhoeae infection
Bacterial infection
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 ¦Ìg/mL.
PRICE 424
DESCRIPTION Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 ??g/mL).
DESCRIPTION Zoliflodacin is a first-in-class spiropyrimidinetrione antibacterial compound that is in development for the treatment of gonorrhea . The compound inhibits bacterial type II topoisomerases with a unique mode of action. (GtoPdb)
DESCRIPTION Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL). (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
34203
ChEMBL Drugs
CHEMBL3544978
Drug Repurposing Hub
DrugBank
DB12817
DrugMAP
DMM6G5D
Guide to Pharmacology
10875
MedChem Express Bioactive Compound Library
HY-17647
TargetMol Bioactive Compound Library
TQ0063
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
487.15
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
6
Aromatic Ring Count
2
cLogP
1.2
TPSA
143.31
Fraction CSP3
0.5
Chiral centers
4.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
DNA gyrase
DNA/RNA Synthesis
Topoisomerase
antibiotic
MOA
antibacterial
Pathway
Cell Cycle/Checkpoint
DNA Damage/DNA Repair
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Source data