General
Preferred name
CROLIBULIN
Synonyms
EPC2407 ()
Crolibulina ()
Crolibuline ()
EPC-2407 ()
EPC 2407 ()
P&D ID
PD058365
CAS
1000852-17-4
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Thyroid cancer
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Crolibulin (EPC2407) is a tubulin polymerization inhibitor, with potent apoptosis induction and cell growth inhibition. Crolibulin has anti-tumor activity. Crolibulin also has cardiovascular toxicity and neurotoxicity[1][2][3].
PRICE
198
DESCRIPTION
Crolibulin, also known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
0
Compound Sets
6
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
416.05
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
2.85
TPSA
129.54
Fraction CSP3
0.17
Chiral centers
1.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
tubulin polymerization
Apoptosis
Microtubule/Tubulin
MOA
tubulin polymerization inhibitor
Pathway
Cytoskeletal Signaling
Cell Cycle/DNA Damage
cytoskeleton
Source data
