General
Preferred name
Delpazolid
Synonyms
LCB01-0371 ()
LCB-010371 ()
LCB-01-0371 ()
Lcb01-0371 ()
P&D ID
PD058263
CAS
1219707-39-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Pulmonary tuberculosis
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Delpazolid is a novel oxazolidinone antibiotic agent which can inhibit the growth of MSSA and MRSA with a MIC90 of 2 ¦Ìg/mL for both of them.
PRICE 49
DESCRIPTION Delpazolid (LCB01-0371) is an oxazolidinone antibacterial that was developed for antitubercular activity. (GtoPdb)
DESCRIPTION Delpazolid (LCB01-0371), also known as LCB01-0371, is a new oxazolidinone with cyclic amidrazone. In vitro activity of LCB01-0371 against 624 clinical isolates was evaluated and compared with those of linezolid, vancomycin, and other antibiotics. LCB01-0371 showed good activity against Gram-positive pathogens. In vivo activity of LCB01-0371 against systemic infections in mice was also evaluated. LCB01-0371 was more active than linezolid against these systemic infections. LCB01-0371 showed bacteriostatic activity against Staphylococcus aureus. (TargetMol Bioactive Compound Library)
Compound Sets
8
Cayman Chemical Bioactives
25532
ChEMBL Drugs
CHEMBL1673408
Drug Repurposing Hub
DrugBank
DB13077
Guide to Pharmacology
10999
MedChem Express Bioactive Compound Library
HY-100180
ReFrame library
TargetMol Bioactive Compound Library
T4165
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
308.13
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
0.84
TPSA
68.61
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Antibacterial
antibiotic
Bacterial
Pathway
Microbiology/virology
Anti-infection
Source data