General
Preferred name
ORG-25935
Synonyms
ORG 25935 ()
SCH-900435 ()
ORG 25935 hydrochloride ()
Sch 900435 ()
Org 25935 ()
Org-25935 free base ()
P&D ID
PD058176
CAS
1147011-84-4
949588-40-3
Tags
available
drug candidate
Drug indication
Psychotic disorder
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ORG 25935 hydrochloride is a potent and selective glycine transporter 1 (GlyT-1) or reuptake inhibitor intended for the treatment of neurological disorders such as schizophrenia.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
339.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
2
cLogP
3.41
TPSA
49.77
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GlyT-1 inhibitor
Source data
