General
Preferred name
AZD-5423
Synonyms
AZD5423 ()
Azd 5423 ()
Azd5423 ()
P&D ID
PD058161
CAS
1034148-04-3
Tags
available
drug candidate
Drug indication
Chronic obstructive pulmonary disease
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2].
PRICE
79
DESCRIPTION
AZD5423 was originally reported as a selective glucocorticoid receptor modulator (SGRM) and investigated for anti-inflammatory potential . Using a virtual screening strategy it has subsequently been shown to inhibit activation of receptor interacting serine/threonine kinase 3 (RIPK3) .
(GtoPdb)
DESCRIPTION
AZD-5423 is a nonsteroidal glucocorticoid. It is used to treat respiratory diseases and in particular chronic obstructive pulmonary disease. It was developed by AstraZeneca.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
AZD5423 is an inhaled, potent, selective, and non-steroidal modulator of the glucocorticoid receptor (GR) that effectively reduces allergen-induced responses in individuals with mild allergic asthma.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
487.15
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
4
cLogP
5.36
TPSA
65.38
Fraction CSP3
0.2
Chiral centers
2.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Glucocorticoid Receptor
Pathway
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Solubility
10 mM in DMSO
Source data
