General
Preferred name
Darexaban
Synonyms
YM 150 ()
Darexaban, Tanexaban ()
YM150 ()
Darexaban maleate ()
Tanexaban ()
YM-150 ()
P&D ID
PD058157
CAS
365462-24-4
365462-23-3
Tags
available
drug candidate
Drug indication
Acute coronary syndrome
Atrial fibrillation
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Darexaban (YM150) is a potent, selective and orally active factor Xa (FXa) inhibitor with an IC50 of 54.6 nM. Darexaban shows high selectivity against other related serine proteases, such as trypsin, thrombin, and kallikrein. Darexaban has anticoagulant and antithrombotic effects[1][2][3].
PRICE 140
DESCRIPTION Darexaban (Tanexaban, YM-150) is a direct inhibitor of Factor Xa.Darexaban and Darexaban glucuronide selectively and competitively inhibit FXA and inhibit prothrombin activity at the site of blood clot (thrombus) formation. This leads to a reduction in blood clot formation in a dose-dependent manner. Reducing clotting will reduce blockages in blood flow, which may reduce the risk of myocardial infarction, unstable angina, venous thrombosis, and ischemic stroke. (TargetMol Bioactive Compound Library)
Compound Sets
6
ChEMBL Drugs
CHEMBL1922235
DrugBank
DB12289
DrugMAP
DMC40SD
MedChem Express Bioactive Compound Library
HY-14853
ReFrame library
TargetMol Bioactive Compound Library
T31206
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
474.23
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
4.05
TPSA
94.14
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
7.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Factor Xa
Ser/Thr Protease
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data