General
Preferred name
SABARUBICIN
Synonyms
Sabarubicin hydrochloride ()
Sabarubicine ()
Sabarubicina ()
P&D ID
PD058077
CAS
211100-13-9
169317-77-5
428506-53-0
Tags
drug candidate
Drug indication
Solid tumour/cancer
Neoplasm
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Sabarubicin is a disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
643.23
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
7
Rotatable Bonds
6
Ring Count
6
Aromatic Ring Count
2
cLogP
-0.13
TPSA
235.53
Fraction CSP3
0.53
Chiral centers
10.0
Largest ring
6.0
QED
0.17
Structural alerts
1
quinone_A(370)
[!#6&!#1]=[#6]1[#6]=,:[#6][#6](=[!#6&!#1])[#6]=,:[#6]1
PAINS Family A
Related compounds
Custom attributes
(extracted from source data)
Source data
