General
Preferred name
RIMEGEPANT
Synonyms
BMS 927711 ()
BMS-927711 ()
BMS927711 ()
BHV-3000 ()
Rimegepant (BMS-927711) ()
RIMEGEPANT SULFATE ()
Vydura ()
Rimegepant hemisulfate sesquihydrate ()
Nurtec odt ()
P&D ID
PD058039
CAS
1289023-67-1
Tags
available
drug
Approved by
EMA
FDA
First approval
2020
Drug indication
Migraine
Trigeminal neuralgia
migraine disorder
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Rimegepant (BMS-927711, BHV-3000) is a small molecule calcitonin gene-related peptide (CGRP) receptor antagonist .
(GtoPdb)
DESCRIPTION
Rimegepant (BMS-927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM and an IC50 of 0.14 nM for hCGRP receptor[1].
PRICE
166
DESCRIPTION
Rimegepant (BMS 927711) is a highly potent, oral calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki value of 0.027 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
534.22
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
6
Aromatic Ring Count
4
cLogP
4.49
TPSA
119.13
Fraction CSP3
0.36
Chiral centers
3.0
Largest ring
7.0
QED
0.37
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CGRP
CGRP Receptor
CALCA
MOA
calcitonin antagonist
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Recommended Cell Concentration
10 nM
Source data
