General
Preferred name
Ziritaxestat
Synonyms
GLPG1690 ()
GLPG-1690 ()
Ziritaxestat (GLPG1690) ()
Glpg1690 ()
G-451990 ()
G451990 ()
Ziritaxestatn ()
P&D ID
PD057961
CAS
1628260-79-6
Tags
available
drug candidate
probe
Drug Status
investigational
Max Phase
Phase 3
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GLPG1690 is an autotaxin Inhibitor , being investigated for anti-fibrotic efficacy.
DESCRIPTION Ziritaxestat (GLPG1690) is a selective autotaxin Inhibitor , that was investigated for anti-fibrotic efficacy. Animal studies using GLPG1690 suggested potential for autotaxin inhibition in breast cancer treatment and TSC2-loss associated oncogenicity (in tuberous sclerosis complex) . In early 2021 data from the phase 3 ziritaxestat program in idiopathic pulmonary fibrosis (IPF; ISABELA) was analysed, and the conclusion reached was that ziritaxestat's benefit-risk profile did not support continuing the program. At that time the decision was made to discontinue the inhibitor's phase 2 trial in systemic sclerosis. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
Cell lines
2
Organisms
0
Compound Sets
12
Axon Medchem Screening Library
3094
Cayman Chemical Bioactives
25498
ChEMBL Drugs
CHEMBL3828074
Chemical Probes.org
ziritaxestat
Drug Repurposing Hub
DrugBank
DB15403
EU-OPENSCREEN Bioactive Compound Library
EOS100080
Guide to Pharmacology
9561
MedChem Express Bioactive Compound Library
HY-101772
ReFrame library
Selleckchem Bioactive Compound Library
ziritaxestat
TargetMol Bioactive Compound Library
T4041
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
588.24
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
6
Aromatic Ring Count
4
cLogP
3.43
TPSA
104.24
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
autotaxin
ATX inhibitor
Phosphodiesterase (PDE)
PDE
ENPP2
MOA
Autotaxin inhibitor
Target class
Enzyme
Target subclass
pyrophosphatase/phosphodiesterase
Source data