General
Preferred name
PF-06372222
Synonyms
P&D ID
PD057943
CAS
1407592-99-7
Tags
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Negative allosteric modulator of the GLP-1 receptor.
(GtoPdb)
DESCRIPTION
PF-06372222 is a small molecule negative allosteric modulator (NAM) of glucagon receptor (GCGR), which helps treat type 2 diabetes. It is also an antagonist of the glucagon-like peptide-1 receptor GLP-1R, which can inhibit glucagon secretion and glucose-dependent insulin secretion.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
2
BOC Sciences Bioactive Compounds
Guide to Pharmacology
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
8
Molecular Weight
515.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
4
Aromatic Ring Count
3
cLogP
5.08
TPSA
109.14
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Solubility
Soluble in DMSO
Source data
