General
Preferred name
AZD 3147
Synonyms
AZD3147 ()
AZD-3147 ()
P&D ID
PD057707
CAS
1101810-02-9
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K[1].
PRICE 361
DESCRIPTION AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3K??, PI3K??, PI3K??, and PI3K??, respectively.
DESCRIPTION AZD-3147 is an extremely potent and selective dual inhibitor of mTORC1 and mTORC2. It exhibits >300-fold selectivity for mTOR over PI 3-kinase isoforms. It has physicochemical and pharmacokinetic properties suitable for development as a potential clinical candidate. (BOC Sciences Bioactive Compounds)
DESCRIPTION AZD 3147 is an inhibitor of mTORC with IC50s of 40.7 and 5.75 nM for mTORC1 and mTORC2. AZD 3147 shows IC50s of 912, 5495, 9333, and 6310 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively. (TargetMol Bioactive Compound Library)
DESCRIPTION Potent and selective JAK2 inhibitor; antiangiogenic (Tocris Bioactive Compound Library)
Compound Sets
7
BOC Sciences Bioactive Compounds
azd-3147-cas-1101810-02-9-item-475059
Cayman Chemical Bioactives
22474
Mcule NIBR MoA Box Subset
MCULE-8776524032
MedChem Express Bioactive Compound Library
HY-12652
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T36200
Tocris Bioactive Compound Library
5615
External IDs
15
Properties
(calculated by RDKit )
Molecular Weight
517.18
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
8
Ring Count
5
Aromatic Ring Count
2
cLogP
2.21
TPSA
116.68
Fraction CSP3
0.54
Chiral centers
1.0
Largest ring
6.0
QED
0.45
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
mTOR
MOA
Inhibitor
Dual inhibitor of mTORC1 and mTORC2
Member status
virtual
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Target
MTOR
mTORC1
mTORC2
Solubility
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Source data