General
Preferred name
ALUMINUM SULFATE
Synonyms
ALUMINUM SULFATE ANHYDROUS ()
Aluminum sesquisulfate ()
INS-520 ()
Sulfuric acid, aluminum salt ()
Aluminium sulfate anhydrous ()
NSC-54563 ()
Aluminum sulphate anhydrous ()
Fertosan ()
Alum cake ()
Sulfuric acid, aluminium salt ()
E-520 ()
Aluminii sulfas, anhydrous ()
INS NO.520 ()
Aluminium sulfate, anhydrous ()
P&D ID
PD057294
CAS
55892-56-3
10043-01-3
10124-29-5
Tags
available
drug
inorganic
Drug Status
approved
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Aluminum sulfate may be used as a deodorant, as well as an astringent [L2160]. Aluminum sulfate is also known as an astringent. Astringents are substances that cause contraction or shrinkage of tissues and that dry up secretion [L2160].; ; Used as a post-shaving treatment, it can eliminate bleeding from superficial wounds [L2157], [L2164]. ; ; It has also shown in vitro anti-microbial activity [L2160].;
MOA When used as a deodorant, the volume of sweat produced is reduced by narrowing sweat ducts. The inhibition of body odor causing bacteria is another important strategy for deodorization [L2160]. ; ; By inhibiting or deactivating odor-producing bacteria, there is little to none metabolism of sweat components thus decreasing the occurrence of body odor [L2160]. ; ; Recent studies suggest that the active binding of alum to the membranes of dendritic cells (DCs) result in alteration of lipid membranes structures as a key process in alum's adjuvant effect in vaccines. As new adjuvants are being developed, alum may remain as an ingredient of adjuvant combinations, or it may eventually be supplemented by other agents that more effectively provide depot and local inflammatory responses to accentuate host immune responses [L2158].
ABSORPTION The degree of aluminum absorption depends on a number of factors, such as the aluminum salt ingested, pH (for aluminum speciation and solubility), bioavailability, as well as dietary conditions [L2149].; ; These facts should be taken into consideration during tissue dosimetry and response assessment to aluminum sulfate. It can be concluded that the use of currently available animal studies to develop a guideline value is inappropriate at this time due to the above specific toxicokinetic/dynamic factors that may affect results [L2149].
Compound Sets
3
ChEMBL Drugs
CHEMBL3833402
DrugBank
DB11239
DrugBank Approved Drugs
DB11239
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
341.82
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-4.78
TPSA
240.78
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.23
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data