General
Preferred name
BASMISANIL
Synonyms
RG1662 ()
RO5186582 ()
Basmisanil, RG1662 ()
RO-5186582 ()
RG-1662 ()
Basmisanil ()
P&D ID
PD057186
CAS
1159600-41-5
Tags
available
drug candidate
Drug indication
Cognitive impairment
Immune dysregulation
Alzheimer disease
Complete androgen insensitivity syndrome
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Basmisanil (RG1662) is a small molecule negative allosteric modulator that is selective for gamma-aminobutyric acid (GABA) A receptors alpha 5, GABRA5, which are expressed in discrete brain regions that are associated with cognitive processing . It has been proposed for rescuing learning/memory deficits in individuals with intellectual disabilities such as those associated with Down syndrome . RG1662 has also been described as an inverse agonist of the α5subunit-containing GABAA receptors. (GtoPdb)
Compound Sets
12
Cayman Chemical Bioactives
21137
ChEMBL Drugs
CHEMBL3681419
Drug Repurposing Hub
DrugBank
DB11877
DrugMAP
DMQ8J0U
EU-OPENSCREEN Bioactive Compound Library
EOS100443
Guide to Pharmacology
10427
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL3681419
MedChem Express Bioactive Compound Library
HY-16716
ReFrame library
Selleckchem Bioactive Compound Library
ro5186582
TargetMol Bioactive Compound Library
T7165
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
445.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
2.63
TPSA
102.6
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
GABAA??5
GABA Receptor
MOA
GABA receptor inverse agonist
Source data