General
Preferred name
DDD85646
Synonyms
DDD 85646 ()
DDD-85646 ()
IMP-366 ()
DDD85646 ()
P&D ID
PD057130
CAS
1215010-55-1
Tags
available
probe
Probe info
Probe type
experimental probe
P&D approved
Probe selectivity
family-selective
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis[1][2][3][4].
PRICE 440
DESCRIPTION The pyrazole sulfonamide, DDD85646, was first identified as a potent N-myristoyltransferase (NMT) inhibitor in T. brucei, the parasite that causes African sleeping sickness (trypanosomiasis) . The compound also has antimalarial activity .

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. (BOC Sciences Bioactive Compounds)
DESCRIPTION DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
5
Compound Sets
10
BOC Sciences Bioactive Compounds
ddd85646-cas-1215010-55-1-292058
Cayman Chemical Bioactives
13839
Chemical Probes.org
ddd85646
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
11455
High-quality chemical probes
PD057130
MedChem Express Bioactive Compound Library
HY-103056
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T27135
The Pathogen Box
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
494.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
3.62
TPSA
92.15
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Disease
KINETOPLASTIDS
Target
Parasite
N-myristoyltransferase-1 (NMT-1)
NMT1, NMT2
DNA/RNA Synthesis
Member status
member
MOA
N-Myristoyltransferase Inhibitors
Pathway
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
Target subclass
Acyltransferase
Acyltransferase, Acyltransferase
Target class
Other post-translational modification
Other post-translational modification, Other post-translational modification
Orthogonal probe
IMP-1088
Source data