General
Preferred name
AZD-9496
Synonyms
AZD9496 ()
SERD ()
KE9 ()
cpd 30b ()
AZD9496 (maleate) ()
Azd 9496 ()
AZD 9496 ()
AZD 9496 ()
P&D ID
PD057092
CAS
1639042-08-2
1639042-28-6
Tags
available
drug candidate
probe
Drug indication
Breast cancer
Drug Status
investigational
Max Phase
Phase 1
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
experimental probe
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
89
No orthogonal probes found
Similar probes
4
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Antagonist;Downregulator;Inhibitor
COMMENT
The compound AZD9496 was the lead candidate for orally bioavailable selective estrogen receptor downregulator (SERD) with equivalent potency and preclinical pharmacology to the intramuscular SERD fulvestrant. Most recently, the compound was put on clinical hold and replaced by AZD9833, a backup compound with a superior profile for safety and efficacy. In addition, there is excellent cellular data using two cell lines (MCF-7 and CAMA-1) for AZD9833. AZD9496 should be replaced by AZD9833 as the chemical probe; it still possesses very good properties can be used as a secondary probe. Aug 4 2021 - 9:14pm
MOA
Antagonist, Downregulator, Inhibitor
(Chemical Probes.org)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
12
Cayman Chemical Bioactives
ChEMBL Drugs
Chemical Probes.org
Drug Repurposing Hub
DrugBank
DrugMAP
High-quality chemical probes
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
442.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
5.63
TPSA
56.33
Fraction CSP3
0.32
Chiral centers
2.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Vitamin D Related/Nuclear Receptor
Target
ER??
ESR1
Estrogen Receptor/ERR
Estrogen/progestogen Receptor
MOA
Estrogen receptor agonist
Target subclass
NR3 Subfamily
Source data
