General
Preferred name
ML352
Synonyms
ML 352 ()
ML-352 ()
ML-352 ()
P&D ID
PD057077
CAS
1649450-12-3
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
MLP Probes
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ML352 is a noncompetitive inhibitor of the presynaptic choline transporter (CHT) with Ki;values of 92 and 166 nM for HEK293 cells expressing human CHT and mouse forebrain synaptosomes, respectively[1].
PRICE
106
MOA
Inhibitor
(Chemical Probes.org)
DESCRIPTION
ML352 is a potent and non-competitive inhibitor of the presynaptic choline transporter (CHT; Ki value 92 nM).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
ML-352 is a noncompetitive inhibitor of the presynaptic choline transporter. It inhibits high affinity choline transporter 1 with IC50= 72 nM in HEK293 cell line.
(Enamine Bioactive Compounds)
DESCRIPTION
ML352 is a selective and potent inhibitor of the presynaptic choline transporter (CHT), inhibits non-competitive choline uptake.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Chemical Probes.org
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
Enamine BioReference Compounds
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
MLP Probes
MLSMR Probes +
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
387.22
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
2
cLogP
3.21
TPSA
76.83
Fraction CSP3
0.52
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Classification
Probe
Target
Presynaptic choline transporter
CHT inhibitor
Cholinesterase (ChE)
SLC5A7
Member status
member
MOA
SLC5A7 gene inhibitor
Pathway
Neuroscience
Neuronal Signaling
Target class
Transporter
Target subclass
Solute carrier
Control
CANSAR1840627
Source data
