General
Preferred name
CC-885
Synonyms
3 ()
1(CC-885) ()
CC-885 ()
P&D ID
PD057043
CAS
1010100-07-8
Tags
available
molecular glue
PROTAC
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Structural studies have shown that immunomodulatory drugs bind in a shallow hydrophobic pocket on the surface of cereblon, mediated by a glutarimide ring. The broad activity profile of CC-885 is highly differentiated from that of , and . The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour cells exhibit high sensitivity to CC-885, indicating the clinical potential of this mechanism .
DESCRIPTION Structural studies have shown that thalidomide class immunomodulatory drugs bind in a shallow hydrophobic pocket on the surface of cereblon, that is mediated by a glutarimide ring of the ligand. Binding of small molecules to cereblon can alter its substrate specificity . Thalidomide and its related drugs enhance recruitment of Ikaros and Aiolos to the E3 ubiquitin ligase complex. CC-885 has a different mechanism of action compared to , and . The anti-tumour activity of CC-885 is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. Patient-derived acute myeloid leukaemia tumour cells exhibit high sensitivity to CC-885, indicating the clinical potential of this mechanism . (GtoPdb)
DESCRIPTION CC-885 is a cereblon modulator (EC50 = 0.0019nM) with antiproliferative effects. (Enamine Bioactive Compounds)
DESCRIPTION CC-885 is a modulator of cereblon (CRBN). It has potent anti-tumour activity. (TargetMol Bioactive Compound Library)
Cell lines
20
Organisms
0
Compound Sets
9
Axon Medchem Screening Library
2645
Cayman Chemical Bioactives
19966
Enamine Bioactive Compounds
EBC-253180
Guide to Pharmacology
9224
MedChem Express Bioactive Compound Library
HY-101488
MolGlueDB
348
ReFrame library
Selleckchem Bioactive Compound Library
cc-885
TargetMol Bioactive Compound Library
T14893
External IDs
13
Properties
(calculated by RDKit )
Molecular Weight
440.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
2.73
TPSA
107.61
Fraction CSP3
0.27
Chiral centers
1.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Cereblon
Ligand for E3 Ligase
E1/E2/E3 Enzyme
Cereblon (CRBN) modulator
Ligands for E3 Ligase
Molecular Glues
E3 Ligase
Pathway
Metabolic Enzyme/Protease
Source data