General
Preferred name
AZADIRACHTIN
Synonyms
Azadirachtin ()
AZADIRACTIN ()
P&D ID
PD057007
CAS
11141-17-6
170906-04-4
Tags
available
drug candidate
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-§ÜB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells[1][2][3][4][5][6].
PRICE
443
DESCRIPTION
Azadirachtin has antifungal activity, used as an insecticide.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
720.26
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
8
Aromatic Ring Count
0
cLogP
-0.2
TPSA
215.34
Fraction CSP3
0.77
Chiral centers
16.0
Largest ring
6.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Antifection
Apoptosis
Bcl-2 Family
Caspase
NF-κB
Parasite
Pathway
Microbiology/virology
Anti-infection
NF-¦ÊB
Source data
