General
Preferred name
ENCALERET
Synonyms
MK-5442 ()
Encaleret sulfate ()
CLTX-305 ()
JTT-305 ()
MK5442 ()
Jit-305 ()
P&D ID
PD056949
CAS
787583-71-5
1214922-52-7
Tags
available
drug candidate
Drug indication
Osteoporosis
Hypoparathyroidism
Postmenopausal osteoporosis
Drug Status
investigational
Max Phase
2.0
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Encaleret (CLTX-305) is an oral calcium sensing receptor (CaSR) negative allosteric modulator (calcilytic). (GtoPdb)
DESCRIPTION Encaleret (CLTX-305) is an orally active antagonist of the calcium-sensing receptor (CaSR), with an IC50 of 0.012 ¦ÌM. Encaleret can promote the secretion of parathyroid hormone. Encaleret can be used in the research of diseases such as osteoporosis and autosomal dominant hypocalcemia type 1[1][2].
DESCRIPTION Encaleret is a calcium-sensing receptor (CaSR) antagonist. But in Oct 2011, Phase-II for Osteoporosis in USA was discontinued. (BOC Sciences Bioactive Compounds)
DESCRIPTION This active molecular is an CaSR (calcium-sensing receptor antagonist) under the developmet of Tobacco and Merck & Co. Calcium-sensing receptor is a member of the G protein-coupled receptor and it is very important to modulate Ca2+ homeostasis via its role in the parathyroid glands and kidneys. Encaleret was used for the treatment of osteoporosis., but was discontinued in Phase-II in Japan, India and USA in 2011. (BOC Sciences Bioactive Compounds)
Compound Sets
11
BOC Sciences Bioactive Compounds
encaleret-cas-787583-71-5-item-459654
encaleret-sulfate-cas-1214922-52-7-item-475155
ChEMBL Drugs
CHEMBL1672973
CHEMBL2105731
Concise Guide to Pharmacology 2017/18
9474
Concise Guide to Pharmacology 2019/20
9474
Concise Guide to Pharmacology 2021/22
9474
Concise Guide to Pharmacology 2023/24
9474
DrugBank
DB18096
DrugMAP
DMHTIGU
Guide to Pharmacology
9474
MedChem Express Bioactive Compound Library
HY-14401
ReFrame library
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
513.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
11
Ring Count
3
Aromatic Ring Count
3
cLogP
6.2
TPSA
78.79
Fraction CSP3
0.34
Chiral centers
2.0
Largest ring
6.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CaSR
Thyroid hormone receptor
Pathway
GPCR/G protein
Vitamin D Related/Nuclear Receptor
Solubility
Soluble in DMSO
Source data