General
Preferred name
Zatolmilast
Synonyms
BPN14770 ()
Zatolmilast (BPN14770) ()
BPN-14770 ()
P&D ID
PD055136
CAS
1606974-33-7
Tags
available
drug candidate
Drug indication
Alzheimer disease
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1].
PRICE 211
DESCRIPTION BPN14770 is reported as a selective allosteric inhibitor of phosphodiesterase 4D (PDE4D) . BPN14770 achieves isotype selectivity by binding to a single amino acid difference on the UCR2 regulatory domain of PDE4D that controls access of cAMP substrate to the enzyme's catalytic site. Dimeric isoforms of PDE4D appear to be important for normal brain function , with abnormally/inappropriately active isoform dimers being associated with intellectual disability . (GtoPdb)
DESCRIPTION Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3). (TargetMol Bioactive Compound Library)
Compound Sets
11
AdooQ Bioactive Compound Library
A18663
Axon Medchem Screening Library
3148
Cayman Chemical Bioactives
34075
ChEMBL Drugs
CHEMBL4541964
DrugBank
DB14790
DrugMAP
DMWVPO0
EUbOPEN Chemogenomics Library
EUB0002777
Guide to Pharmacology
10451
MedChem Express Bioactive Compound Library
HY-117571
Selleckchem Bioactive Compound Library
bpn14770
TargetMol Bioactive Compound Library
T10590
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
405.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
5.64
TPSA
50.19
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Phosphodiesterase (PDE)
PDE4D3
PDE4D7
phosphodiesterase
PDE4D inhibitor
PDE
Pathway
Metabolism
Metabolic Enzyme/Protease
Recommended Cell Concentration
None
Source data