General
Preferred name
BTRX-335140
Synonyms
CYM-53093 ()
Navacaprant ()
NAVACAPRANT HYDROCHLORIDE ()
CYM53093 ()
Nmra-335140 ()
BTRX335140 ()
BTRX-140 ()
NMRA-140 ()
NMRA335140 ()
NMRA-335140 hydrochloride ()
NMRA-335140 HCl ()
CYM53093 HYDROCHLORIDE ()
BTRX-335140 hydrochloride ()
BTRX335140 HYDROCHLORIDE ()
NMRA335140 HYDROCHLORIDE ()
CYM-53093 HYDROCHLORIDE ()
P&D ID
PD055135
CAS
2244614-14-8
Tags
available
drug candidate
Drug indication
depressive disorder
Major depressive disorder
Drug Status
investigational
Max Phase
1.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Navacaprant (NMRA-140; formerly BTRX-335140, a.k.a. CYM-53093) is a selective κ opioid receptor antagonist . It had favourable drug-like properties in preclinical models, and was proposed as a potential therapeutic for migraine , stress-related mood disorders (including depression), anxiety, and drug abuse. Neumora Therapeutics acquired BTRX-335140 in their buyout of Blackthorn Therapeutics. The chemical structure for NMRA-140 matches that for the INN navacaprant.
(GtoPdb)
PRICE
397
DESCRIPTION
BTRX-335140 (CYM-53093) is a potent and selective orally active ??-opioid receptor (KOR) antagonist with antagonistic activity against ??OR, ??OR, and ??OR with IC50 values of 0.8, 110, and 6500 nM, respectively.
DESCRIPTION
BTRX-335140 (CYM-53093) is a potent and selective orally active κ-opioid receptor (KOR) antagonist with antagonistic activity against κOR, μOR, and δOR with IC50 values of 0.8, 110, and 6500 nM, respectively.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
ChEMBL Drugs
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
453.25
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
4.34
TPSA
76.31
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Opioid Receptor
δ-opioid receptor
κ-opioid receptor
μ-opioid receptor
Pathway
GPCR/G protein
Neuronal Signaling
Endocrinology/Hormones
Neuroscience
Source data
