General
Preferred name
SEP-363856
Synonyms
SEP-856 hydrochloride ()
Ulotaront (hydrochloride) ()
SEP-363856 (hydrochloride) ()
SEP-856 (hydrochloride) ()
SEP-363856 HCl ()
SEP-363856 hydrochloride ()
ULOTARONT ()
ULOTARONT HYDROCHLORIDE ()
SEP-856 ()
SEP-363856-01 ()
P&D ID
PD055131
CAS
1310426-33-5
1310422-41-3
Tags
available
drug candidate
Drug indication
Major depressive disorder
Schizophrenia
Parkinson disease
Drug Status
investigational
Max Phase
3.0
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ulotaront (SEP-363856) is an orally active and brain-penetrant psychotropic agent with a novel mechanism of action. It acts as a trace amine-associated receptor 1 (TAAR1) agonist with additional 5-HT1A receptor agonist activity, and agonism at both of these receptors appears to be required for its clinical effects . SEP-363856 is being developed by Sunovion Pharmaceuticals and PsychoGenics, and was granted FDA Breakthrough Therapy Designation as an anti-schizophrenia therapeutic in May 2019. The lack of D2 receptor activity distinguishes SEP-363856 from current antipsychotic medications.
In the Dedic et al. article from 2019 SEP-363856 refers to the hydrochloride salt. We show the parent molecule here. This S enantiomer is more active at TAAR1 compared to the R stereoenantiomer . (GtoPdb)
In the Dedic et al. article from 2019 SEP-363856 refers to the hydrochloride salt. We show the parent molecule here. This S enantiomer is more active at TAAR1 compared to the R stereoenantiomer . (GtoPdb)
DESCRIPTION
SEP-363856 (SEP-856) hydrochloride, an orally active TAAR1 and 5-HT1A agonist and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 hydrochloride has the potential for the study of schizophrenia[1].
PRICE
143
DESCRIPTION
SEP-363856 is a psychotropic drug with CNS activity and a unique non-D2/5-HT2A mechanism of action.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
SEP-363856 HCl is a psychotropic drug with CNS activity and a unique non-D2/5-HT2A mechanism of action.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
183.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
1.58
TPSA
21.26
Fraction CSP3
0.56
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT Receptor
5-HT1A
5-HT1B
5-HT1D
5-HT2A
5-HT2C
5-HT7
amine-associated receptor 1 (TAAR1)
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Solubility
Soluble in DMSO
Source data
