General
Preferred name
Islatravir
Synonyms
MK-8591 ()
EFdA ()
ISLATRAVIR HYDRATE ()
Mk-8591 ()
Islatravir anhydrous ()
Islatravir monohydrate ()
MK-8591 MONOHYDRATE ()
P&D ID
PD055077
CAS
865363-93-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
viral disease
HIV-1 infection
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
190
DESCRIPTION
Islatravir (MK-8591) is an effective anti-HIV-1 agent. It acts as a nucleoside reverse transcriptase inhibitor (EC50s: 0.068 nM, 3.1 nM, and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively).
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
6
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
293.09
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.81
TPSA
119.31
Fraction CSP3
0.42
Chiral centers
3.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIV-1
Reverse Transcriptase
NRT inhibitor
Pathway
Microbiology/virology
Proteases/Proteasome
Source data
