General
Preferred name
Brensocatib
Synonyms
AZD7986 ()
INS 1007 ()
AZD 7986 ()
AZD-7986 ()
INS-1007 ()
Azd7986 ()
INS1007 ()
P&D ID
PD053904
CAS
1802148-05-5
Tags
available
covalent binder
drug
Drug indication
Coronavirus Disease 2019 (COVID-19)
Bronchiectasis
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Brensocatib (AZD7986) is an oral dipeptidyl peptidase 1 (DPP1) inhibitor with pIC50s of 6.85, 7.6, 7.7, 7.8, and 7.8 in human, mouse, rat, dog and rabbit, respectively[1].
PRICE 248
DESCRIPTION Brensocatib (formerly AZD7986) is reported as a second generation, oral, selective and reversible inhibitor of dipeptidyl peptidase 1 (DPP1; a.k.a. cathepsin C) . Cathepsin C is required for the activation of proinflammatory neutrophil serine proteases, making this enzyme a drug target whose pharmacological inhibition has potential in the treatment of diseases such as chronic obstructive pulmonary disease (COPD) which is driven in part by excessive neutrophil activation and dysregulated neutrophil elastase activity. The compound was originally developed by AstraZeneca, but is now being progressed by Insmed. (GtoPdb)
DESCRIPTION Brensocatib (AZD7986) is a Dipeptidyl peptidase 1 (DPP1) inhibitor (pIC50s: 6.85, 7.7, 7.6, 7.8, and 7.8 in human, rat, mouse, rabbit, and dog, respectively). (TargetMol Bioactive Compound Library)
Compound Sets
13
Axon Medchem Screening Library
2766
Cayman Chemical Bioactives
33184
ChEMBL Drugs
CHEMBL3900409
CovalentInDB
CI001571
Drug Repurposing Hub
DrugBank
DB15638
DrugMAP
DMT2C78
Guide to Pharmacology
9412
Mcule NIBR MoA Box Subset
MCULE-5935694924
MedChem Express Bioactive Compound Library
HY-101056
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
TQ0038
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
420.18
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
1.73
TPSA
109.29
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
7.0
QED
0.65
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Dipeptidyl Peptidase
Dipeptidyl peptidase 1 (DPP1)
DPP1
Member status
member
MOA
DPP1 inhibitor
dipeptidyl peptidase inhibitor
Therapeutic Class
Antiviral Agents
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Ubiquitination
Source data