General
Preferred name
Nanvuranlat
Synonyms
KYT-0353 ()
KYT-0353 dihydrochloride ()
KYT 0353 ()
JPH203 free base ()
JPH203 Dihydrochloride ()
JPH203 ()
JPH203 (hydrochloride) ()
P&D ID
PD053891
CAS
1597402-27-1
1037592-40-7
Tags
available
drug candidate
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
KYT-0353 (JPH203) is a potent and selective inhibitor of L-type amino acid transporter 1 (SLC7A5) , that is being investigated as an anti-cancer agent. Structurally it is a tyrosine analog.
(GtoPdb)
PRICE
116
PRICE
308
DESCRIPTION
JPH203 (KYT-0353) is a potent and specific inhibitor of L-type amino acid transporter protein 1 (LAT-1). JPH203 inhibits cellular uptake of leucine, inhibits cell proliferation, induces apoptosis, and possesses anti-inflammatory and anti-tumor activities.
(TargetMol Bioactive Compound Library)
DESCRIPTION
LAT1 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
JPH203 is a potent and selective inhibitor of L-type amino acid transporter 1 (LAT1), which is highly expressed in many tumor cells. Study has shown that JPH203 inhibited L-leucine uptake, and increased apoptosis rates and formed DNA ladder in Saos2 cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
JPH203 dihydrochloride (KYT-0353 dihydrochloride) is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
12
BOC Sciences Bioactive Compounds
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
Guide to Pharmacology
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
25
Molecular Weight
471.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
4
cLogP
4.92
TPSA
124.6
Fraction CSP3
0.13
Chiral centers
1.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Autophagy
LAT1
Primary Target
Other Ion Pumps/Transporters
MOA
Inhibitor
solute carrier family member inhibitor
Source data
