General
Preferred name
THIOACETAMIDE
Synonyms
TAA ()
Acetothioamide ()
Thiacetamide ()
P&D ID
PD053481
CAS
62-55-5
1482-80-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model[1][2][3][4].
PRICE 98
DESCRIPTION Thioacetamide is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide induces acute chronic liver injury through the activation of protein synthesis of RNA, DNA, and gamma-glutamyl transpeptitase. (Enamine Bioactive Compounds)
DESCRIPTION Thioacetamide is a hepatotoxicant used widely to induce experimental liver lesions, develops hepatocellular necrosis and subsequent inflammation (mainly M1-/M2-macrophages without neutrophil infiltration) in rats. (TargetMol Bioactive Compound Library)
Compound Sets
5
Enamine Bioactive Compounds
EBC-151064
MedChem Express Bioactive Compound Library
HY-Y0698
NURSA ligand set
nursa/index.jsf?doi=10.1621%2F78D82792E0
Selleckchem Bioactive Compound Library
thioacetamide
TargetMol Bioactive Compound Library
T35367
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
75.01
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
0.29
TPSA
26.02
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.42
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Necroptosis
Pathway
Apoptosis
Source data