General
Preferred name
TP-472
Synonyms
TP 472 ()
TP-472 ()
P&D ID
PD053447
CAS
2079895-62-6
Tags
available
probe
Probe info
Probe type
P&D approved
experimental probe
Probe selectivity
protein-selective
Probe sources
Bromodomains chemical toolbox
Chemical Probes.org
High-quality chemical probes
SGC Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION TP-472 is a selective BRD9/7 inhibitor, with Kds of 33 nM and 340 nM for BRD9 and BRD7, respectively. TP-472 exhibits >30-fold selectivity for BRD9 over other bromodomain family members except BRD7[1][2]. TP-472 induces apoptosis of melanoma cells[3].
DESCRIPTION TP-472 is a potent BRD9/7 inhibitor tool compound that is cell permeable and active in vivo. TP-472 is one of the chemical tools in the Structural Genomics Consortium's Epigenetic Probes Library. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION TP-472 is an inhibitor of bromodomain BRD9 and BRD7 bromodomain with Kd values of 33 and 340 nM, respectively. (BOC Sciences Bioactive Compounds)
DESCRIPTION Wnt canonical signaling activator; also tubulin polymerization inhibitor (Tocris Bioactive Compound Library)
Cell lines
4
Organisms
0
Compound Sets
12
BOC Sciences Bioactive Compounds
tp-472-cas-2079895-62-6-292429
Bromodomains chemical toolbox
Cayman Chemical Bioactives
20030
Chemical Probes.org
tp-472
CZ-OPENSCREEN Bioactive Library
EUbOPEN Chemogenomics Library
EUB0000231
Guide to Pharmacology
9522
High-quality chemical probes
PD053447
MedChem Express Bioactive Compound Library
HY-100517
Novartis Chemogenetic Library (NIBR MoA Box)
SGC Probes
TP-472
Tocris Bioactive Compound Library
6000
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
333.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
3.4
TPSA
63.47
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
Bromodomains
MOA
Inhibitor
BRD9/BRD7 inhibitor
Member status
member
Pathway
Apoptosis
Epigenetics
Target
BRD9
BRD7
BRD9, BRD7
Epigenetic Reader Domain
Target class
Epigenetic, Epigenetic
Target subclass
Bromodomain, Bromodomain
Control
TP-472N
Recommended Cell Concentration
1 uM
Source data