General
Preferred name
Philanthotoxin 74
Synonyms
PhTx-74 HCl ()
PhTx 74 dihydrochloride ()
Philanthotoxin 74 dihydrochloride ()
Philanthotoxin 74 (hydrochloride) ()
P&D ID
PD053209
CAS
1227301-51-0
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively[1][2].
PRICE
241
DESCRIPTION
GluN1A/GluN2B-selective NMDA antagonist; orally bioavailable
(Tocris Bioactive Compound Library)
DESCRIPTION
Philanthotoxin 74, also called as PhTx-74, is a synthetic analog of the naturally-occurring wasp venom toxin philanthotoxin-4,3,3. Philanthotoxin 74 is an AMPA receptor antagonist, and a non-selective homomeric GluR3 and GluR1 receptor antagonist (IC50= 263 and 296 nM respectively).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
EUbOPEN Chemogenomics Library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
434.33
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
5
Rotatable Bonds
18
Ring Count
1
Aromatic Ring Count
1
cLogP
2.61
TPSA
116.48
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Neuronal Signaling
Primary Target
AMPA Receptors
MOA
Antagonist
Target
iGluR
GluR1
GluR3
GluR5
AMPAR
Recommended Cell Concentration
100 nM
Source data
