General
Preferred name
preclamol
Synonyms
S(-)-3PPP hydrochloride ()
(-)-3PPP, Maryland ()
Preclamol (hydrochloride) ()
(-)-3-PPP (hydrochloride) ()
PRECLAMOL HYDROCHLORIDE ()
(-)-3ppp ()
P&D ID
PD053164
CAS
85966-89-8
85976-54-1
88768-67-6
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Preclamol hydrochloride ((-)-3-PPP hydrochloride) is a selective dopamine autoreceptor agonist. Preclamol hydrochloride has the potential for the research of schizophrenia[1][2].
DESCRIPTION
Dopamine autoreceptor agonist; postsynaptic dopamine receptor antagonist
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
5
ChEMBL Drugs
DrugMAP
LOPAC library
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
219.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
1
cLogP
2.98
TPSA
23.47
Fraction CSP3
0.57
Chiral centers
1.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
Pathway
GPCR/G protein
Neuronal Signaling
Target
Dopamine Receptor
Source data
