General
Preferred name
BREVIANAMIDE F
Synonyms
Cyclo-L-tryptophyl-L-proline ()
cyclo-(L-Trp-L-Pro) ()
Cyclo(L-Pro-L-Trp) ()
Cyclo(L-Pro-L-Trp)cyclo-(L-Trp-L-Pro)Cyclo-L-tryptophyl-L-proline ()
P&D ID
PD052676
CAS
38136-70-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Brevianamide F (Cyclo(L-Pro-L-Trp)) is a mycotoxin isolated from Colletotrichum gloeosporioides, with antibacterial activity. Brevianamide F shows potent PI3K¦Á inhibitory activity with an IC50 of 4.8 ¦ÌM[1][2].
PRICE 60
DESCRIPTION Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), is a naturally occurring 2,5-diketopiperazine with notable breast cancer resistance protein inhibitory activity. (TargetMol Bioactive Compound Library)
Compound Sets
5
AdooQ Bioactive Compound Library
A15926
Cayman Chemical Bioactives
23493
MedChem Express Bioactive Compound Library
HY-100385
Selleckchem Bioactive Compound Library
brevianamide-f
TargetMol Bioactive Compound Library
T3208
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
283.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
1.2
TPSA
65.2
Fraction CSP3
0.38
Chiral centers
2.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
breast cancer resistance protein
PI3K
Pathway
Anti-infection
PI3K/Akt/mTOR
Membrane Transporter/Ion Channel
Microbiology/virology
PI3K/Akt/mTOR signaling
Source data