General
Preferred name
OGLUFANIDE
Synonyms
H-Glu-Trp-OH ()
L-Glutamyl-L-tryptophan ()
H-Glu-Trp-OH, L-Glutamyl-L-tryptophan ()
Oglufanide disodium ()
NSC-334073 ()
Oglufanida ()
Oglufanide sodium ()
Glufanide disodium ()
IM-862 ()
IM862 ()
P&D ID
PD052578
CAS
122933-59-9
237068-57-4
38101-59-6
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
2.0
Drug indication
peritoneum cancer
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
85
DESCRIPTION
Oglufanide (H-Glu-Trp-OH) is a naturally occurring thymic immunomodulator that inhibits vascular endothelial growth factor (VEGF).
DESCRIPTION
Oglufanide disodium is the disodium salt of a synthetic form of a naturally-occurring dipeptide consisting of L-glutamic acid and L-tryptophan with potential antiangiogenic and potential immunomodulating activities. Oglufanide inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
333.13
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
5
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
0.47
TPSA
145.51
Fraction CSP3
0.31
Chiral centers
2.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
VEGF antagonist
Target
Endogenous Metabolite
HCV
VEGFR
Antiviral,Bacterial,VEGFR
Pathway
Anti-infection
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Source data
