General
Preferred name
EXIFONE
Synonyms
NSC 680919 ()
NSC680919 ()
NSC-680919 ()
Exifona ()
P&D ID
PD052320
CAS
52479-85-3
72841-23-7
Tags
available
drug
Drug Status
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 50
DESCRIPTION Exifone (NSC-680919) is a mixed, nonessential activator of HDAC1 that is capable of binding to both free and substrate-bound enzyme, resulting in an increased relative maximal rate of HDAC1-catalyzed deacetylation. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Approved Drugs
CHEMBL329522
ChEMBL Drugs
CHEMBL329522
Drug Repurposing Hub
DrugMatrix
ReFrame library
TargetMol Bioactive Compound Library
T20080
Withdrawn 2.0
w156
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
278.04
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
6
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.15
TPSA
138.45
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HDAC1
TYR
MOA
nootropic agent
ATC
P
Toxicity type
hepatic
Pathway
Chromatin/Epigenetic
DNA Damage/DNA Repair
Source data