General
Preferred name
SODIUM CARBONATE
Synonyms
Disodium carbonate, Soda Ash, Carbonic acid disodium salt ()
Sodium salt of carbonic acid ()
Carbonic acid sodium salt (1:2) ()
Dried sodium carbonate ()
E500 ()
INS-500(I) ()
Carbonic acid, disodium salt ()
Anhydrous sodium carbonate ()
Sodium carbonate (anhydrous) ()
Sodium carbonate, anhydrous ()
Natrum carbonicum ()
Solvay soda ()
Soda ash ()
Sodium carbonate anhydrous ()
NSC-156204 ()
INS NO.500(I) ()
E-500(I) ()
Soda-ash ()
P&D ID
PD052303
CAS
497-19-8
533-96-0
1332-57-6
7542-12-3
Tags
available
drug
Drug Status
approved
Max Phase
Phase 4
Drug indication
Pharmaceutic Aid (alkalizing agent)
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Alkalizing buffering action: Sodium bicarbonate is an alkalinizing agent that dissociates to provide bicarbonate ion. Bicarbonate in excess of that needed to buffer hydrogen ions causes systemic alkalinization and, when excreted, urine alkalinization as well. ; Oral antacid action: Taken orally, sodium bicarbonate neutralizes stomach acid by the above mechanism.
MOA Carbon dioxide from the tissues diffuses rapidly into red blood cells, where it is hydrated with water to form carbonic acid. This reaction is accelerated by carbonic anhydrase, an enzyme present in high concentrations in red blood cells. The carbonic acid formed dissociates into bicarbonate and hydrogen ions. Most of the bicarbonate ions diffuse into the plasma. Since the ratio of H2CO3 to dissolved CO2 is constant at equilibrium, pH may be expressed in terms of bicarbonate ion concentration and partial pressure of CO2 by means of the Henderson-Hasselbach equation:; pH = pk + log [HCO3-]/aPCO2
TOXICITY Man: LD50 (Oral) - 714 mg/kg, Effect: Behavioural,General Anesthetic : GI Ulceration or Bleeding from small intestine.; Mouse : LC50 ( Inhalation ) - 1200mg/m3/2h : GI Other Change; Mouse : LC50 ( Intraperitoneal ) - 117mg/kg; Mouse : LD50 ( Oral) - 6600mg/kg; Mouse : LD50 (Subcutaneous ) - 2210 mg/kg; Rat : LC50 ( Inhalation ) 2300mg/m3/2H; Rat: LD50 (Oral) - 4090 mg/kg
Compound Sets
5
ChEMBL Approved Drugs
CHEMBL186314
ChEMBL Drugs
CHEMBL186314
DrugBank
DB09460
DrugBank Approved Drugs
DB09460
Selleckchem Bioactive Compound Library
sodium-carbonate
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
105.96
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-8.44
TPSA
63.19
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.29
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Source data